The Minasarc study: A case-control study measuring mineral exposome in sarcoidosis

Michel Vincent (1) , Catherine Cavalin (2) , Mickaël Catinon , Cécile Chemarin , Stéphane Rio (3) , Élisabeth Roux (4) , Mathieu Pecquet (3) , Anne-Sophie Blanchet (5) , Sylvie Vuillermoz (3) , Audrey Natalizio , Christophe Pison , François Arbib (6) , Vincent Bonneterre , Dominique Valeyre , Olivia Freynet (7, 8, 9, 10) , Jean-François Mornex , Nathalie Freymond (11, 12) , Yves Pacheco , Françoise Thivolet , Marianne Kambouchner (13, 14) , Jean-François Bernaudin , Paul-Andre Rosental (15)

1 Sciences Po - Sciences Po
2 CEE - Centre d'études européennes et de politique comparée (Sciences Po, CNRS)
3 Hôpital Saint Joseph
4 ESPE Versailles - École supérieure du professorat et de l'éducation - Académie de Versailles
5 UB - Université de Bordeaux
6 Clinique de pneumologie
7 Service de Pneumologie [Bichat]
8 PHERE (UMR_S_1152 / U1152) - Physiopathologie et Epidémiologie des Maladies Respiratoires
9 SU - Sorbonne Université
10 DHU FIRE Centre de compétence des maladies pulmonaires rares
11 CHLS - Centre Hospitalier Lyon Sud [CHU - HCL]
12 Département de Pneumologie [HCL, Lyon]
13 Service d’anatomie pathologique
14 Hôpital Avicenne [AP-HP]
15 CHSP - Centre d'histoire de Sciences Po (Sciences Po)

It has been suggested that sarcoidosis could be associated with exposure to inorganic particles (Newman LS Curr Opin All Clin Immunol 2012; 12:145-50, Vincent M et al Am J Ind Med 2015; 58:S31-8). In order to test this hypothesis the Minasarc study was designed to evaluate the mineral exposome by a specific questionnaire (SQ) and a mineralogical analysis performed on BALs by optical and electron microscopy in patients and healthy volunteers (HV). We present here the results obtained by the SQ which can be considered as a tool for global assessment of the “whole life” exposure to inorganic particles in occupational and environmental contexts. The study was performed on 20 patients with sarcoidosis and 20 HV. Every HV was matched to a patient by sex, age and smoking habit. The SQ was calibrated with a representative sample of the French population (n=825) in the ELIPSSilice survey (ANR-10-Eqpx-19-01) and the result was expressed as a “dust score”. Scores were compared by a Wilcoxon signed-rank test. [Résumé éditeur]

Mots clés: Sarcoidosis; Occupation; Interstitial lung disease

Domaines: Environnement et Société

Michel Vincent, Catherine Cavalin, Mickaël Catinon, Cécile Chemarin, Stéphane Rio, et al.. The Minasarc study: A case-control study measuring mineral exposome in sarcoidosis. European Respiratory Journal, 2016, 48 (suppl 60), ⟨10.1183/13993003⟩. ⟨hal-03434906⟩