Sarcoidosis, inorganic dust exposure and content of bronchoalveolar lavage fluid: the MINASARC pilot study - Archive ouverte HAL Access content directly
Journal Articles Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG / World Association of Sarcoidosis and Other Granulomatous Disorders Year : 2018

Sarcoidosis, inorganic dust exposure and content of bronchoalveolar lavage fluid: the MINASARC pilot study

Mickaël Catinon
  • Function : Author
Cécile Chemarin
  • Function : Author
Mathieu Pecquet
  • Function : Author
Sylvie Vuillermoz
  • Function : Author
Christophe Pison
Vincent Bonneterre
  • Function : Author
Dominique Valeyre
  • Function : Author
Jean-François Mornex
  • Function : Author
Yves Pacheco
  • Function : Author
Françoise Thivolet
  • Function : Author
Jean-François Bernaudin
  • Function : Author
Audrey Nathalizio
  • Function : Author
Pierre Pradat
  • Function : Author
Michel Vincent
  • Function : Author
  • PersonId : 1050719

Abstract

Inhalation of mineral dust was suggested to contribute to sarcoidosis. We compared the mineral exposome of 20 sarcoidosis and 20 matched healthy subjects. Bronchoalveolar lavage (BAL) samples were treated by digestion-filtration and analyzed by transmission electron microscopy. The chemical composition of inorganic particles was determined by energy-dispersive X-ray (EDX) spectroscopy. Dust exposure was also assessed by a specific questionnaire. Eight sarcoidosis patients and five healthy volunteers had a high dust load in their BAL. No significant difference was observed between the overall inorganic particle load of each group while a significant higher load for steel was observed in sarcoidosis patients (p=0.029). Moreover, the building activity sub-score was significantly higher in sarcoidosis patients (p=0.018). These results suggest that building work could be a risk factor for sarcoidosis which could be considered at least in some cases as a granulomatosis caused by airborne inorganic dust. The questionnaire should be validated in larger studies.
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Dates and versions

hal-02184087 , version 1 (15-07-2019)

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Catherine Cavalin, Mickaël Catinon, Cécile Chemarin, Élisabeth Roux, Mathieu Pecquet, et al.. Sarcoidosis, inorganic dust exposure and content of bronchoalveolar lavage fluid: the MINASARC pilot study. Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG / World Association of Sarcoidosis and Other Granulomatous Disorders, 2018, 35 (4), pp.327-332. ⟨10.36141/svdld.v35i4.7058⟩. ⟨hal-02184087⟩
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